I Agree to the Terms and Conditions by entering this website.
By Uwe Blesching
Have you ever wondered what contributes to nature’s abundance of colors and scents that makes being around lush, aromatic plants so delightful? By the same token do you know what natural ingredients contribute to making one of the most basic pleasure of life, the taste of foods, so enjoyable? The answer to both is Flavonoids. Also known as bioflavonoids these natural substances are produced by plants such as citrus fruits, berries, vegetables, tea, cocoa, red wine and cannabis.
Flavonoids are a biologically diverse family of natural substances that help realize a number of beneficial effects to the plants that make them and those who consume them. Named after the Latin word for yellow (flavus) presumably chosen to describe the compounds that influence color schemes in plants but also help to generate their unique flavors and scents. Flavonoids are considered secondary metabolites that function to facilitate biological interactions within the same organism, between other organisms, and the environment. As such, flavonoids are not primary life-sustaining building blocks like sugars, proteins, or lipids but rather plant constituents that realize secondary benefits. In plants they function to attract pollinators, detract pests, protect against shifts in salinity, safeguard against UV light or establish freezing tolerances.
In people (or any other mammal) who consume them, flavonoids can mitigate some of the shared underlying pathologies of numerous chronic conditions and in doing so increase an organisms ability to generate and maintain health and wellness. More specifically, flavonoids help to make the process of managing chronic internal and environmental stressors such as the aging process,1 oxidative stress or inflammation,2 more efficient. Furthermore, if we take into consideration flavonoid’s very low adverse effects potential and its potential protective effects against environmental threats such as various viral diseases including COVID,3 for example it becomes easy to understand why flavonoids are found in a great number of pharmaceutical, nutraceutical, as well as cosmetic products generated across the globe. Indeed, most every Health Agency tasked with educating people about dietary health recommend fruits and vegetables abundant in flavonoids for these very reasons. However, due to their relatively low bioavailability, rapid metabolism, and elimination most people could benefit from an increase intake of flavonoids.
Chemically, flavonoids present with variable phenolic structures (organic aromatic building blocks) that include thousands of individual members. Those that are of dietary importance are typically divided into six major sub-groups (in alphabetical order with food examples): anthocyanidins (blue berries, wine), flavan-3-ols (green tea, cocoa, various spices), flavanones (fresh lemon, fresh oranges), flavones (fresh parsley, fresh thyme, cannabis), flavonols (tea, fresh, raw kale, cannabis), and isoflavones (mature raw soybean seeds, firm, cooked tofu).4 For those readers interested in a bit more technical information flavonoids have a typical molecular structure containing a 15-carbon structure (abr. C6-C3-C6) comprised of three rings (i.e. two phenyl rings each made up of six carbon atoms (A, B) and one heterocyclic ring characterized by 2 atoms of at least 2 elements in this case carbon and oxygen (C).
Cannabis-based flavonoids primarily belong two sub-classes i.e., flavones and flavonols. The earliest paper describing three cannabis-based flavonoids was published by Canadian researchers in 1979.5 By 2021 a team from the US described a total of 34 flavonoids (for a complete list in order of discovery scroll down to the end of article).6
And, while the scientific literature reporting on cannaflavins in the context of health, healing and well-being is relatively small, emerging data is beginning to describe cannflavin-induced effects with potential clinical relevance most notably anti-inflammatory,7 anti-oxidant8 and potential analgesic effects.9 Specific treatment examples include the potential mitigation of neurodegenerative processes with potential relevance to patients with Alzheimer’s disease.10Also of note, the unnatural isomer of Cannflavin B (i.e. FBL-03G) has demonstrated therapeutic potential in preclinical models of metastatic pancreatic cancer notorious for extremely poor survival rates and orthodox treatment responses.11
Consider these emerging facts with potential practical relevance:
Cannabis keeps on surprising us. The evidence-based underpinnings of flavonoids are but one example. Scientists continuously discover novel plant constituents, novel therapeutic effects, and novel complexities, which taken together allows us to make more informed and discerning decisions to amplify the health and wellness generating effects of cannabis-based therapeutics.
When exploring flavonoid profiles consider choosing a cannabis chemotype III (more CBD than THC), consider leaf-based cannabis products (e.g., leaf-based shake/kief), sprout hemp seeds, and/or juice fresh cannabis leaves. Alternatively, to maximize flavonoid content you can utilize fresh cannabis flower. The cannabinoids in fresh flower have not yet decarboxylated (i.e., do not produce cognitive changes) and as such exist in their acid forms with relatively high amounts of flavonoids and terpenes. If the taste is too unpleasant due its bitterness you may want to mix them with carrot juice or chop them up and fill a few gelatin capsules for easier consumption.
Cannabis-Based Flavonoids by Year of Discovery (Radwan et. al. 2021):19
(Clark M.N. and Bohm B.A.):20 Vitexin • cytisoside • cytisoside glucoside
(Turner CE, Elsohly MA, Boeren EG):21
Orientin • orientin-O-glucoside • orientin-7-O-glucoside • orientin-7-O-rhamnoglucoside ••
Vitexin-O-glucoside • vitexin-7-O-glucoside • vitexin-7-O- rhamnoglucoside ••
Isovitexin • isovitexin-O-glucoside • isovitexin-7-O-glucoarbinoside • isovitexin-7-O- rhamnoglucoside • apigenin-7-O-glucoside • apigenin-7-O-glucoronoid • apigenin-7-O-p-coumaroylglucoside ••
Luteolin-C-glucuronid • luteolin-7-0-glucuronid • kaempferol-3-0-diglucoside • quercetin-3-0-glucoside • quercetin-3-0-diglucoside
(Crombie L. and Crombie W.M.L):22 Canniflavone 1 • Canniflavone 2
(Barrett ML, Scutt AM, and Evans FJ):23 Cannflavin A • Cannflavin B (same compounds as above)
(Ross SA, ElSohly MA. et. al.):24 Kaempferol-3-O-sophoroside • quercetin-3-O-sophoroside
(Radwan et. al.):25 Cannflavin C • 6-prenylapigenin • chrysoeriol
(Cheng L., Kong D., and Hu G.):26 Apigenin-6,8-di-C-β-D-glucopyranoside
(Chen B., Cai G. et. al.):27 Rutin
(Ingallina C. et. al.):28 Quercetin • Naringenin • Naringin
“Went into Tweed yesterday and stocked up. Amazing options strain options there were more than 31 as advertised. Signed up and love the people in the store. Very professional. Potent weed.”
“TweedLeaf is one of so few businesses who take their product seriously, as well as their patients. As a picky consumer, everything is top notch! The staff is always kind and professional and informative, and I feel “safe” when on the premises. I would recommend this place only for people who take their needs seriously. Thank you TweedLeaf, I love you guys!”
“I’m still pretty new to this dispensary & I love everything about it!
The prices are amazing, as well as the products! The people are really nice & it makes me feel more welcome & happy to to make this my main dispensary.”
“Came from out of state. It’s a great dispensary with a wide selection of products and great customer service.”
“TweedLife has exceptional staff at all locations I’ve been to thus far and all the products we’ve tried have been added to our favorites! I have yet to be disappointed! Some favorites are Starfighter, Bruce Banner, Pineapple Express, Blue Lemon Thai, Skywalker…really they have all been amaaaazing!”
“I always receive quick, courteous service here. I am always impressed by their vast selection of various MMJ products. All their medical MMJ products are of top shelf quality for a fair price.”